Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication

被引：29

作者：

Chung, Chungwon

Lee, Wonhee

Loffredo, John T.

Burwitz, Benjamin

Friedrich, Thomas C.

Vela, Juan Pablo Giraldo

Napoe, Gnankang

Rakasz, Eva G.

Wilson, Nancy A.

Allison, David B.

Watkins, David I.

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA

[3] Univ Alabama, Dept Biostat, Birmingham, AL 35294 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 03期

关键词：

D O I：

10.1128/JVI.01780-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Current assays of CD8(+) T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8(+) T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef(165-173)IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2.

引用

页码：1517 / 1523

页数：7

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