Benzylidine pregnenolones and their oximes as potential anticancer agents: Synthesis and biological evaluation

被引：42

作者：

Banday, Abid H. ^{[1
,2
]}

Akram, S. M. M. ^{[1
,3
]}

Shameem, Shameem A. ^{[1
]}

机构：

[1] Islamia Coll Sci & Commerce, Dept Chem, Srinagar 190009, Jammu & Kashmir, India

[2] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

[3] Univ Kashmir, Dept Chem, Srinagar 190002, Jammu & Kashmir, India

来源：

STEROIDS | 2014年 / 84卷

关键词：

Benzylidine pregnenolone; Aldol condensation; Nucleophillic addition; Cytoxicity; Dehydration; DERIVATIVES;

D O I：

10.1016/j.steroids.2014.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The present study reveals the anticancer activity of benzylidine pregnenolones and their oxime derivatives. The synthesis of the analogs of both series is very simple and involves aldol condensation in the first step followed by nucleophillic addition of hydroxylamine across carbonyl in the second step. Quantitative yields of more than 80% are obtained in both the steps. All the compounds were tested for their cytotoxic activities against a panel of six human cancer cell lines. Amongst all the compounds of both the series screened for their cytotoxic actvity, compound 3e, 3f and 4e are very potent especially against HCT-15 and MCF-7 cancer cell lines. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：64 / 69

页数：6

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