Preparation of tertiary amides from carbamoyl chlorides and organocuprates

被引：19

作者：

Lemoucheux, L ^{[1
]}

Seitz, T ^{[1
]}

Rouden, J ^{[1
]}

Lasne, MC ^{[1
]}

机构：

[1] Univ Caen, ENSICaen, CNRS, UMR 6507,Lab Chim Mol & Thioorgan, F-14050 Caen, France

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 21期

关键词：

D O I：

10.1021/ol0487130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of carbamoyl chlorides with cyano-Gilman cuprates affords tertiary amides in good to excellent yields. The reaction is general due to the possibility of using reagents made either from organolithium or from Grignard compounds. The characterization of the main side products allowed for the suggestion of a possible mechanism.

引用

页码：3703 / 3706

页数：4

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