Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis

被引：42

作者：

Koyama, J ^{[1
]}

Morita, I

Tagahara, K

Nobukuni, Y

Mukainaka, T

Kuchide, M

Tokuda, H

Nishino, H

机构：

[1] Kobe Pharmaceut Univ, Fac Pharmaceut Sci, Higashinada Ku, Kobe, Hyogo 658, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 602, Japan

来源：

CANCER LETTERS | 2002年 / 182卷 / 02期

关键词：

anti-tumor promoting effect; emodin; cassiamin B;

D O I：

10.1016/S0304-3835(02)00100-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In continuation of our works of natural and synthetic products as cancer chemopreventive agents, we have examined emodin and cassiamin B, which were isolated from Cassia siamea. These compounds exhibited the remarkable anti-tumor promoting effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by both topical application. Furthermore, emodin exhibited potent inhibitory activity on two-stage carcinogenesis test of mouse skin tumors induced by nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide as an initiator and TPA as a promoter. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 139

页数：5

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