Model organisms - Drug discovery in dementia: the role of rodent models

被引：153

作者：

Van Dam, Debby

De Deyn, Peter Paul

机构：

[1] Univ Antwerp, Dept Biomed Sci, Inst Born Bunge, Lab Neurochem & Behav, B-2610 Antwerp, Belgium

[2] Middelheim Hosp, ZNA, Dept Neurol, Memory Clin, B-2020 Antwerp, Belgium

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrd2075

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent advances in the understanding of the pathophysiological mechanisms underlying Alzheimer's disease have pointed to novel strategies for drug development. Animal models have contributed considerably to these advances, and will have a key role in the evaluation of therapeutics that could have the potential not just to alleviate the dementia associated with Alzheimer's disease, but to modify the disease process. Here, we summarize and critically evaluate current rodent models of dementia, and discuss their role in drug discovery and development.

引用

收藏

页码：956 / 970

页数：15

相关论文

共 97 条

[41] β-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis [J].

Harkany, T ;

Abrahám, I ;

Timmerman, W ;

Laskay, G ;

Tóth, B ;

Sasvári, M ;

Kónya, C ;

Sebens, JB ;

Korf, J ;

Nyakas, C ;

Zarándi, M ;

Soós, K ;

Penke, B ;

Luiten, PGM .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (08) :2735-2745

[42] Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease [J].

Hauss-Wegrzyniak, B ;

Dobrzanski, P ;

Stoehr, JD ;

Wenk, GL .

BRAIN RESEARCH, 1998, 780 (02) :294-303

[43] β-amyloid deposition and tau phosphorylation in clinically characterized aged cats [J].

Head, E ;

Moffat, K ;

Das, P ;

Sarsoza, E ;

Poon, WW ;

Landsberg, G ;

Cotman, CW ;

Murphy, MP .

NEUROBIOLOGY OF AGING, 2005, 26 (05) :749-763

[44] Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1-42 levels in APPV717I transgenic mice [J].

Heneka, MT ;

Sastre, M ;

Dumitrescu-Ozimek, L ;

Hanke, A ;

Dewachter, I ;

Kuiperi, C ;

O'Banion, K ;

Klockgether, T ;

Van Leuven, F ;

Landreth, GE .

BRAIN, 2005, 128 :1442-1453

[45] Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice [J].

Hsiao, K ;

Chapman, P ;

Nilsen, S ;

Eckman, C ;

Harigaya, Y ;

Younkin, S ;

Yang, FS ;

Cole, G .

SCIENCE, 1996, 274 (5284) :99-102

[46] Characterization of transgenic mice expressing apolipoprotein E4(C112R) and apolipoprotein E4(L28P; C112R) [J].

Huber, G ;

März, W ;

Martin, JR ;

Malherbe, P ;

Richards, JG ;

Sueoka, N ;

Ohm, T ;

Hoffmann, MM .

NEUROSCIENCE, 2000, 101 (01) :211-218

[47] Metabolic regulation of brain Aβ by neprilysin [J].

Iwata, N ;

Tsubuki, S ;

Takaki, Y ;

Shirotani, K ;

Lu, B ;

Gerard, NP ;

Gerard, C ;

Hama, E ;

Lee, HJ ;

Saido, TC .

SCIENCE, 2001, 292 (5521) :1550-1552

[48] The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats [J].

Janas, AM ;

Cunningham, SC ;

Duffy, KB ;

Devan, BD ;

Greig, NH ;

Holloway, HW ;

Yu, QS ;

Markowska, AL ;

Ingram, DK ;

Spangler, EL .

LIFE SCIENCES, 2005, 76 (10) :1073-1081

[49] Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice [J].

Janelsins, Michelle C. ;

Mastrangelo, Michael A. ;

Oddo, Salvatore ;

LaFerla, Frank M. ;

Federoff, Howard J. ;

Bowers, William J. .

JOURNAL OF NEUROINFLAMMATION, 2005, 2 (1)

[50] ON THE ROLE OF THE HIPPOCAMPUS IN LEARNING AND MEMORY IN THE RAT [J].

JARRARD, LE .

BEHAVIORAL AND NEURAL BIOLOGY, 1993, 60 (01) :9-26

← 1 2 3 4 5 6 7 8 9 10 →