Model organisms - Drug discovery in dementia: the role of rodent models

被引：153

作者：

Van Dam, Debby

De Deyn, Peter Paul

机构：

[1] Univ Antwerp, Dept Biomed Sci, Inst Born Bunge, Lab Neurochem & Behav, B-2610 Antwerp, Belgium

[2] Middelheim Hosp, ZNA, Dept Neurol, Memory Clin, B-2020 Antwerp, Belgium

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrd2075

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent advances in the understanding of the pathophysiological mechanisms underlying Alzheimer's disease have pointed to novel strategies for drug development. Animal models have contributed considerably to these advances, and will have a key role in the evaluation of therapeutics that could have the potential not just to alleviate the dementia associated with Alzheimer's disease, but to modify the disease process. Here, we summarize and critically evaluate current rodent models of dementia, and discuss their role in drug discovery and development.

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页码：956 / 970

页数：15

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