Reprogramming the Methylome: Erasing Memory and Creating Diversity

被引：252

作者：

Lee, Heather J. ^{[1
,2
]}

Hore, Timothy A. ^{[1
]}

Reik, Wolf ^{[1
,2
,3
]}

机构：

[1] Babraham Inst, Epigenet Programme, Cambridge CB22 3AT, England

[2] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

[3] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England

来源：

CELL STEM CELL | 2014年 / 14卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

EMBRYONIC STEM-CELLS; PRIMORDIAL GERM-CELLS; DNA METHYLATION; GROUND-STATE; NAIVE PLURIPOTENCY; HISTONE METHYLATION; SYSTEMS BIOLOGY; DEMETHYLATION; GENOME; DYNAMICS;

D O I：

10.1016/j.stem.2014.05.008

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular memory that ensures faithful commitment to transcriptional programs during mammalian development. Epigenetic reprogramming results in global hypomethylation of the genome together with a profound loss of memory, which underlies naive pluripotency. Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem cells where reciprocal molecular links connect the methylation machinery to pluripotency. Priming for differentiation is initiated upon exit from pluripotency, and we propose that epigenetic mechanisms create diversity of transcriptional states, which help with symmetry breaking during cell fate decisions and lineage commitment.

引用

页码：710 / 719

页数：10

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