In vivo photoacoustic imaging of blood vessels with a pulsed laser diode

被引:122
作者
Kolkman, Roy G. M.
Steenbergen, Wiendelt
van Leeuwen, Ton G.
机构
[1] Univ Twente, Fac Sci & Technol, Inst BioMed Technol, NL-7500 AE Enschede, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Ctr Laser, NL-1100 DE Amsterdam, Netherlands
关键词
imaging techniques; ultrasound; blood vessels;
D O I
10.1007/s10103-006-0384-z
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Photoacoustic imaging is a hybrid imaging modality that is based on the detection of acoustic waves generated by absorption of pulsed light by tissue chromophores such as hemoglobin in blood. For this technique, usually large and costly Q-switched Nd:YAG lasers are used. These lasers provide a pulse energy of at least several milliJoules. In search of alternative light sources, we investigated the use of a small and compact pulsed laser diode to image blood vessels. We proved that a pulsed laser diode can be applied for imaging blood vessels in vivo.
引用
收藏
页码:134 / 139
页数:6
相关论文
共 17 条
[1]   Generating photoacoustic signals using high-peak power pulsed laser diodes. [J].
Allen, TJ ;
Cox, BT ;
Beard, PC .
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2005, 2005, 5697 :233-242
[2]   Imaging of venous valves with photoacoustics [J].
Bosschaart, Nienke ;
Kolkman, Roy ;
van Leeuwen, Ton ;
Steenbergen, Wiendelt .
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2006, 2006, 6086
[3]   A new theoretical approach to photoacoustic signal generation [J].
Hoelen, CGA ;
de Mul, FFM .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1999, 106 (02) :695-706
[4]   Photoacoustic determination of blood vessel diameter [J].
Kolkman, RGM ;
Klaessens, JHGM ;
Hondebrink, E ;
Hopman, JCW ;
de Mul, FFM ;
Steenbergen, W ;
Thijssen, JM ;
van Leeuwen, TG .
PHYSICS IN MEDICINE AND BIOLOGY, 2004, 49 (20) :4745-4756
[5]   Photoacoustic imaging of blood vessels with a double-ring sensor featuring a narrow angular aperture [J].
Kolkman, RGM ;
Hondebrink, E ;
Steenbergen, W ;
van Leeuwen, TG ;
de Mul, FFM .
JOURNAL OF BIOMEDICAL OPTICS, 2004, 9 (06) :1327-1335
[6]   In vivo photoacoustic imaging of blood vessels using an extreme-narrow aperture sensor [J].
Kolkman, RGM ;
Hondebrink, E ;
Steenbergen, W ;
de Mul, FFM .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2003, 9 (02) :343-346
[7]   Thermoacoustic computed tomography using a conventional linear transducer array [J].
Kruger, RA ;
Kiser, WL ;
Reinecke, DR ;
Kruger, GA .
MEDICAL PHYSICS, 2003, 30 (05) :856-860
[8]   Thermoacoustic CT of the breast: Pilot study observations [J].
Kruger, RA ;
Kiser, WL .
BIOMEDICAL OPTOACOUSTICS II, 2001, 4256 :1-5
[9]   Thermoacoustic molecular imaging of small animals [J].
Kruger, Robert A. ;
Kiser, William L. ;
Reinecke, Daniel R. ;
Kruger, Gabe A. ;
Miller, Kathy D. .
Molecular Imaging, 2003, 2 (02) :113-123
[10]   The Twente Photoacoustic Mammoscope: system overview and performance [J].
Manohar, S ;
Kharine, A ;
van Hespen, JCG ;
Steenbergen, W ;
van Leeuwen, TG .
PHYSICS IN MEDICINE AND BIOLOGY, 2005, 50 (11) :2543-2557