Migratory fate and differentiation of blood monocyte subsets

被引:399
作者
Tacke, Frank
Randolph, Gwendalyn J.
机构
[1] Univ Hosp Aachen, Med Clin 3, Aachen, Germany
[2] CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY USA
关键词
dendritic cells; differentiation; macrophages; migration; monocytes;
D O I
10.1016/j.imbio.2006.05.025
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Monocytes are established circulating precursors for tissue macrophages and dendritic cells (DCs). Monocyte-derived macrophages and DCs fulfill critical roles in innate and adaptive immunity during inflammation, and it is believed that monocytes also maintain these populations in peripheral tissues during homeostasis. However, the continuous replenishment of any DC pool by blood monocytes in the steady state remains to be established, and some macrophage populations may be self-renewing in the steady state. Recent identification of mouse monocyte subsets that closely resemble human monocyte subsets has inspired a variety of techniques wherein monocytes can be readily traced in vivo to address these critical questions. There are two major monocyte subsets that vary in chemokine receptor (CCR) and adhesion molecule expression, and in migratory and differentiation properties. In humans, 'classical' CD14(+) CD16(-) monocytes express CCR2, CD64, CD62L, whereas 'non-classical' CD14(low) CD16(+) monocytes lack CCR2. Their counterparts in mice are CCR2(+) Gr-1(hi) and CCR2(-) Gr-1(low) monocytes, respectively. Gr-1(hi) (Ly6C(hi)) monocytes are recruited to inflammatory sites, e.g. inflamed skin or acutely inflamed peritoneum and give rise to macrophages and DCs in inflammatory or infectious disease models and to epidermal Langerhans cells after skin inflammation. Gr-1(low) monocytes have been proposed as precursors for steady state DCs, but experimental evidence is as of yet limited. Fortunately, the rate of progress in the study of monocyte fate is rapidly picking up pace, giving rise to the expectation that we will soon know much more about the biology of monocytes in the steady state and inflammation. (c) 2006 Elsevier GmbH. All rights reserved.
引用
收藏
页码:609 / 618
页数:10
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