Transcription under the control of nuclear Arm/β-catenin

被引：163

作者：

Staedeli, Reto ^{[1
]}

Hoffmans, Raymond ^{[1
]}

Basler, Konrad ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Biol, CH-8057 Zurich, Switzerland

来源：

CURRENT BIOLOGY | 2006年 / 16卷 / 10期

关键词：

D O I：

10.1016/j.cub.2006.04.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Wingless/Wnt pathway controls cell fates during animal development and regulates tissue homeostasis as well as stem cell number and differentiation in epithelia. Deregulation of Wnt signaling has been associated with cancer in humans. In the-nucleus, the Wingless/Wnt signal is transmitted via the key effector protein Armadillo/beta-catenin. The recent identification and functional analysis of novel Armadillo/beta-catenin interaction partners provide new and exciting insights into the highly complex mechanism of Wingless/Wnt target gene activation.

引用

页码：R378 / R385

页数：8

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