Interleukin-6 and rheumatic diseases

被引：88

作者：

Lipsky, Peter E. ^{[1
]}

机构：

[1] NIAMSD, Autoimmun Branch, NIH, Bethesda, MD 20892 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2006年 / 8卷 / Suppl 2期

关键词：

D O I：

10.1186/ar1918

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of the inflammatory and immunologic responses in certain autoimmune diseases. Blocking of these two complementary functions of IL-6 may confer additive, or even unique, benefits to the patient. The levels of both IL-6 and its soluble receptor (slL-6R alpha) are elevated to various degrees in many rheumatic diseases. IL-6 blockade has been shown to be beneficial both in experimental models and in human disease, and inhibition of IL-6 signaling with a molecule such as tocilizumab could prevent or reverse some of the complications typically associated with rheumatic diseases.

引用

页数：5

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