Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity

被引：70

作者：

An, Ning ^{[1
,2
]}

Zou, Zhong-mei ^{[1
,2
]}

Tian, Ze ^{[1
,2
]}

Luo, Xiu-zhen ^{[1
,2
]}

Yang, Shi-lin ^{[3
]}

Xu, Li-zhen

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China

[2] Peking Union Med Coll, Beijing 100094, Peoples R China

[3] Jiang Xi Chinese Med Coll, Nanchang 330006, Peoples R China

来源：

FITOTERAPIA | 2008年 / 79卷 / 01期

关键词：

Alpinia officinarum; Diarylheptanoids; Cytotoxic activity;

D O I：

10.1016/j.fitote.2007.07.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new diarylheptanoids (1, 2), together with two known analogs (3, 4), were isolated from the rhizomes of Alpinia officinarum. The new compounds were elucidated to be (5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-l-phenyl-3-heptanone (1) and (5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-l-phenyl-3-heptanone (2) based on their spectral analysis. Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：27 / 31

页数：5

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