A new antiplatelet diarylheptanoid from Alpinia blepharocalyx

被引:71
作者
Dong, H
Chen, SX
Xu, HX
Kadota, S
Namba, T
机构
[1] Natl Univ Singapore, Biosci Ctr, Singapore 119260, Singapore
[2] Dalhousie Univ, Dept Chem, Halifax, NS B3H 3J5, Canada
[3] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Toyama 93001, Japan
来源
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期
关键词
D O I
10.1021/np970293i
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-(1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Structures of these compounds were elucidated by spectroscopic and chemical means.
引用
收藏
页码:142 / 144
页数:3
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