A new antiplatelet diarylheptanoid from Alpinia blepharocalyx

被引：71

作者：

Dong, H

Chen, SX

Xu, HX

Kadota, S

Namba, T

机构：

[1] Natl Univ Singapore, Biosci Ctr, Singapore 119260, Singapore

[2] Dalhousie Univ, Dept Chem, Halifax, NS B3H 3J5, Canada

[3] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Toyama 93001, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期

关键词：

D O I：

10.1021/np970293i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-(1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Structures of these compounds were elucidated by spectroscopic and chemical means.

引用

页码：142 / 144

页数：3

共 15 条

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