Synthesis of novel chiral binaphthyl phosphorus ligands and their applications in Rh-catalyzed asymmetric hydrogenation

被引：56

作者：

Chi, YX ^{[1
]}

Zhang, XM ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 27期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(02)00877-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series or new chiral mono- or bidentate phosphorous ligands were efficiently prepared through a key intermediate (S)-4-chloro-4.5-dihydro-3H-4-phosphacyclohepta[2,1-a:3.4-a']binaphthalene and its derivatives These ligands were applied in the Rh-catalyzed asymmetric hydrogenation of a-dehydro amino acids, enol acetates, itaconates, and enamides. Good to excellent enantioselectivities were obtained (up to 99.5% ee). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4849 / 4852

页数：4

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