In search of peptide-based catalysts for asymmetric organic synthesis

被引：364

作者：

Miller, SJ ^{[1
]}

机构：

[1] Boston Coll, Chestnut Hill, MA 02467 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 08期

关键词：

D O I：

10.1021/ar030061c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The discovery of short peptide sequences that function as asymmetric catalysts for a variety of reactions is documented. The evolution of the project from an exercise in rational design to an endeavor that combines combinatorial screening with various mechanism-based experiments is presented. The specific development of catalysts for enantioselective acylation, phosphorylation, conjugate addition, and Morita-Baylis-Hillman reactions is described.

引用

页码：601 / 610

页数：10

共 88 条

[81]

Urbaniak G. C., RES RANDOMIZER VERSI

[82]

Vasbinder MM, 2001, ANGEW CHEM INT EDIT, V40, P2824, DOI 10.1002/1521-3773(20010803)40:15<2824::AID-ANIE2824>3.0.CO

[83]

2-J

[84] A comparison of monocyclic and bicyclic phospholanes as acyl-transfer catalysts [J].

Vedejs, E ;

Daugulis, O ;

Harper, LA ;

MacKay, JA ;

Powell, DR .

JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (13) :5020-5027

[85] Design of folded peptides [J].

Venkatraman, J ;

Shankaramma, SC ;

Balaram, P .

CHEMICAL REVIEWS, 2001, 101 (10) :3131-3152

[86]

Vogl EM, 1999, ANGEW CHEM INT EDIT, V38, P1570, DOI 10.1002/(SICI)1521-3773(19990601)38:11<1570::AID-ANIE1570>3.0.CO

[87]

2-Y

[88] Privileged chiral catalysts [J].

Yoon, TP ;

Jacobsen, EN .

SCIENCE, 2003, 299 (5613) :1691-1693

← 1 2 3 4 5 6 7 8 9 →