MicroRNAs As Novel Regulators of Angiogenesis

被引：361

作者：

Suarez, Yajaira ^{[2
,3
]}

Sessa, William C. ^{[1
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA

[3] Yale Univ, Sch Med, Vasc Biol & Therapeut Program, New Haven, CT 06519 USA

来源：

CIRCULATION RESEARCH | 2009年 / 104卷 / 04期

关键词：

endothelial cells; Dicer; gene expression; VEGF; cancer; ENDOTHELIAL GROWTH-FACTOR; ANGIOTENSIN-II; IN-VIVO; PROTEIN-SYNTHESIS; ENZYME DICER; POSTTRANSCRIPTIONAL REGULATION; TRANSCRIPTION FACTORS; ARGONAUTE PROTEINS; TARGETED DELETION; CELL-SURVIVAL;

D O I：

10.1161/CIRCRESAHA.108.191270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis. (Circ Res. 2009;104:442-454.)

引用

页码：442 / 454

页数：13

共 143 条

[61] Role of dicer and drosha for endothelial MicroRNA expression and angiogenesis [J].

Kuehbacher, Angelika ;

Urbich, Carmen ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2007, 101 (01) :59-68

[62] A microRNA component of the hypoxic response [J].

Kulshreshtha, R. ;

Davuluri, R. V. ;

Calin, G. A. ;

Ivan, M. .

CELL DEATH AND DIFFERENTIATION, 2008, 15 (04) :667-671

[63] A microRNA signature of hypoxia [J].

Kulshreshtha, Ritu ;

Ferracin, Manuela ;

Wojcik, Sylwia E. ;

Garzon, Ramiro ;

Alder, Hansjuerg ;

Agosto-Perez, Francisco J. ;

Davuluri, Ramana ;

Liu, Chang-Gong ;

Croce, Carlo M. ;

Negrini, Massimo ;

Calin, George A. ;

Ivan, Mircea .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (05) :1859-1867

[64] T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice [J].

Kumar, Priti ;

Ban, Hong-Seok ;

Kim, Sang-Soo ;

Wu, Haoquan ;

Pearson, Todd ;

Greiner, Dale L. ;

Laouar, Amale ;

Yao, Jiahong ;

Haridas, Viraga ;

Habiro, Katsuyoshi ;

Yang, Yong-Guang ;

Jeong, Ji-Hoon ;

Lee, Kuen-Yong ;

Kim, Yong-Hee ;

Kim, Sung Wan ;

Peipp, Matthias ;

Fey, Georg H. ;

Manjunath, N. ;

Shultz, Leonard D. ;

Lee, Sang-Kyung ;

Shankar, Premlata .

CELL, 2008, 134 (04) :577-586

[65] Identification of tissue-specific microRNAs from mouse [J].

Lagos-Quintana, M ;

Rauhut, R ;

Yalcin, A ;

Meyer, J ;

Lendeckel, W ;

Tuschl, T .

CURRENT BIOLOGY, 2002, 12 (09) :735-739

[66] Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation [J].

le Sage, Carlos ;

Nagel, Remco ;

Egan, David A. ;

Schrier, Mariette ;

Mesman, Elly ;

Mangiola, Annunziato ;

Anile, Corrado ;

Maira, Giulio ;

Mercatelli, Neri ;

Ciafre, Silvia Anna ;

Farace, Maria Giulia ;

Agami, Reuven .

EMBO JOURNAL, 2007, 26 (15) :3699-3708

[67] MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression [J].

Lee, Daniel Y. ;

Deng, Zhaoqun ;

Wang, Chia-Hui ;

Yang, Burton B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (51) :20350-20355

[68] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

[69] The nuclear RNase III Drosha initiates microRNA processing [J].

Lee, Y ;

Ahn, C ;

Han, JJ ;

Choi, H ;

Kim, J ;

Yim, J ;

Lee, J ;

Provost, P ;

Rådmark, O ;

Kim, S ;

Kim, VN .

NATURE, 2003, 425 (6956) :415-419

[70] MicroRNA genes are transcribed by RNA polymerase II [J].

Lee, Y ;

Kim, M ;

Han, JJ ;

Yeom, KH ;

Lee, S ;

Baek, SH ;

Kim, VN .

EMBO JOURNAL, 2004, 23 (20) :4051-4060

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