MicroRNAs As Novel Regulators of Angiogenesis

被引：361

作者：

Suarez, Yajaira ^{[2
,3
]}

Sessa, William C. ^{[1
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA

[3] Yale Univ, Sch Med, Vasc Biol & Therapeut Program, New Haven, CT 06519 USA

来源：

CIRCULATION RESEARCH | 2009年 / 104卷 / 04期

关键词：

endothelial cells; Dicer; gene expression; VEGF; cancer; ENDOTHELIAL GROWTH-FACTOR; ANGIOTENSIN-II; IN-VIVO; PROTEIN-SYNTHESIS; ENZYME DICER; POSTTRANSCRIPTIONAL REGULATION; TRANSCRIPTION FACTORS; ARGONAUTE PROTEINS; TARGETED DELETION; CELL-SURVIVAL;

D O I：

10.1161/CIRCRESAHA.108.191270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis. (Circ Res. 2009;104:442-454.)

引用

页码：442 / 454

页数：13

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