Solid phase synthesis of 5,6,7,8-tetrahydro-1H-imidazo[4,5-g]quinoxalin-6-ones

被引：28

作者：

Mazurov, A ^{[1
]}

机构：

[1] Nanosyn Inc, Tucson, AZ 85747 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 01期

关键词：

solid phase synthesis; imidazo[4,5-g]quinoxaline; combinatorial chemistry;

D O I：

10.1016/S0040-4039(99)01993-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Traceless solid phase synthesis of 5,6,7,8-tetrahydro-1H-imidazo[4,5-g]quinoxalin-6-ones with three points of diversity is described. Primary amines attached to 2-(4-formyl-3-methoxyphenoxy)ethyl polystyrene react with 1,5-difluoro-2,4-dinitrobenzene followed by displacement of second fluorine with amino acid ester, reduction of nitro groups, acylation and ring closure. A library of 60 title compounds has been prepared. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7 / 10

页数：4

共 18 条

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