Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry

被引：51

作者：

del Fresno, M

Alsina, J

Royo, M

Barany, G

Albericio, F

机构：

[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 17期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)00226-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diketopiperazines, which are cyclic dipeptides, are often formed by a side reaction of solid-phase peptide synthesis. Using the new "Backbone Amide Linker," this chemistry can be conveniently harnessed for the intentional preparation of diketopiperazines. These products will be useful scaffolds for combinatorial chemistry, since they incorporate three different points of diversity: both amino acid side-chains and one (of the two) amide bonds. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2639 / 2642

页数：4

共 35 条

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