The emerging role of E2F-1 in the DNA damage response and checkpoint control

被引：105

作者：

Stevens, C ^{[1
]}

La Thangue, NB ^{[1
]}

机构：

[1] Univ Glasgow, Div Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

基金：

英国医学研究理事会;

关键词：

E2F-1; DNA repair; DNA damage;

D O I：

10.1016/j.dnarep.2004.03.034

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1071 / 1079

页数：9

共 89 条

[1]

BARTEK J, 2003, CANCER CELL, V3, P21

[2] p14ARF links the tumour suppressors RB and p53 [J].

Bates, S ;

Phillips, AC ;

Clark, PA ;

Stott, F ;

Peters, G ;

Ludwig, RL ;

Vousden, KH .

NATURE, 1998, 395 (6698) :124-125

[3] ATM is a target for positive regulation by E2F-1 [J].

Berkovich, E ;

Ginsberg, D .

ONCOGENE, 2003, 22 (02) :161-167

[4]

Blattner C, 1999, MOL CELL BIOL, V19, P3704

[5] DNA replication control through interaction of E2F-RB and the origin recognition complex [J].

Bosco, G ;

Du, W ;

Orr-Weaver, TL .

NATURE CELL BIOLOGY, 2001, 3 (03) :289-295

[6] Requirements for cell cycle arrest by p16INK4a [J].

Bruce, JL ;

Hurford, RK ;

Classon, M ;

Koh, J ;

Dyson, N .

MOLECULAR CELL, 2000, 6 (03) :737-742

[7] Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 [J].

Canman, CE ;

Lim, DS ;

Cimprich, KA ;

Taya, Y ;

Tamai, K ;

Sakaguchi, K ;

Appella, E ;

Kastan, MB ;

Siliciano, JD .

SCIENCE, 1998, 281 (5383) :1677-1679

[8] Characterization of the 5′Flanking Region of the Human Chk1 Gene Identification of E2F1 Functional Sites [J].

Carrassa, Laura ;

Broggini, Massimo ;

Vikhanskaya, Faina ;

Damia, Giovanna .

CELL CYCLE, 2003, 2 (06) :604-609

[9]

Chehab NH, 2000, GENE DEV, V14, P278

[10]

Ciechanover A, 2000, BIOESSAYS, V22, P442, DOI 10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO

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