The emerging role of E2F-1 in the DNA damage response and checkpoint control

被引：105

作者：

Stevens, C ^{[1
]}

La Thangue, NB ^{[1
]}

机构：

[1] Univ Glasgow, Div Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

基金：

英国医学研究理事会;

关键词：

E2F-1; DNA repair; DNA damage;

D O I：

10.1016/j.dnarep.2004.03.034

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1071 / 1079

页数：9

共 89 条

[11]

2-Q

[12] Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks [J].

Cortez, D ;

Wang, Y ;

Qin, J ;

Elledge, SJ .

SCIENCE, 1999, 286 (5442) :1162-1166

[13] The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling [J].

D'Amours, D ;

Jackson, SP .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (05) :317-327

[14] Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation [J].

de Bruin, A ;

Maiti, B ;

Jakoi, L ;

Timmers, C ;

Buerki, R ;

Leone, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (43) :42041-42049

[15] Distinct roles for E2F proteins in cell growth control and apoptosis [J].

DeGregori, J ;

Leone, G ;

Miron, A ;

Jakoi, L ;

Nevins, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7245-7250

[16]

DELAVAINE L, IN PRESS E2F 7 DISTI

[17] E2F-1 functions in mice to promote apoptosis and suppress proliferation [J].

Field, SJ ;

Tsai, FY ;

Kuo, F ;

Zubiaga, AM ;

Kaelin, WG ;

Livingston, DM ;

Orkin, SH ;

Greenberg, ME .

CELL, 1996, 85 (04) :549-561

[18] Apaf-1 is a mediator of E2F-1-induced apoptosis [J].

Furukawa, Y ;

Nishimura, N ;

Furukawa, Y ;

Satoh, M ;

Endo, H ;

Iwase, S ;

Yamada, H ;

Matsuda, M ;

Kano, Y ;

Nakamura, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39760-39768

[19] E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control [J].

Gaubatz, S ;

Lindeman, GJ ;

Ishida, S ;

Jakoi, L ;

Nevins, JR ;

Livingston, DM ;

Rempel, RE .

MOLECULAR CELL, 2000, 6 (03) :729-735

[20] Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor [J].

Giangrande, PH ;

Hallstrom, TC ;

Tunyaplin, C ;

Calame, K ;

Nevins, JR .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (11) :3707-3720

← 1 2 3 4 5 6 7 8 9 →