The emerging role of E2F-1 in the DNA damage response and checkpoint control

被引：105

作者：

Stevens, C ^{[1
]}

La Thangue, NB ^{[1
]}

机构：

[1] Univ Glasgow, Div Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

基金：

英国医学研究理事会;

关键词：

E2F-1; DNA repair; DNA damage;

D O I：

10.1016/j.dnarep.2004.03.034

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1071 / 1079

页数：9

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