Protein-mediated fatty acid uptake: Novel insights from in vivo models

被引：176

作者：

Doege, Holger ^{[1
]}

Stahl, Andreas

机构：

[1] Palo Alto Med Fdn Res Inst, Palo Alto, CA USA

[2] Stanford Univ, Sch Med, Div GI Hepatol, Stanford, CA 94305 USA

来源：

PHYSIOLOGY | 2006年 / 21卷

关键词：

D O I：

10.1152/physiol.00014.2006

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Long-chain fatty acids are both important metabolites as well as signaling molecules. Fatty acid transport proteins are key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.

引用

收藏

页码：259 / 268

页数：10

相关论文

共 99 条

[1] Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm [J].

Abumrad, N ;

Coburn, C ;

Ibrahimi, A .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1999, 1441 (01) :4-13

[2] A defect in the transport of long-chain fatty acids associated with acute liver failure [J].

Al Odaib, A ;

Shneider, BL ;

Bennett, MJ ;

Pober, BR ;

Reyes-Mugica, M ;

Friedman, AL ;

Suchy, FJ ;

Rinaldo, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (24) :1752-1757

[3] Fatty acid utilization in the hypertrophied and failing heart: Molecular regulatory mechanisms [J].

Barger, PM ;

Kelly, DP .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1999, 318 (01) :36-42

[4] MOLECULAR-BIOLOGY OF MAMMALIAN GLUCOSE TRANSPORTERS [J].

BELL, GI ;

KAYANO, T ;

BUSE, JB ;

BURANT, CF ;

TAKEDA, J ;

LIN, D ;

FUKUMOTO, H ;

SEINO, S .

DIABETES CARE, 1990, 13 (03) :198-208

[5] A novel relative of the very-long-chain Acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern [J].

Berger, J ;

Truppe, C ;

Neumann, H ;

Forss-Petter, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 247 (02) :255-260

[6] Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans [J].

Binnert, C ;

Koistinen, HA ;

Martin, GV ;

Andreelli, F ;

Ebeling, P ;

Koivisto, VA ;

Laville, M ;

Auwerx, J ;

Vidal, H .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 279 (05) :E1072-E1079

[7] IDENTIFICATION OF A NOVEL GENE ENCODING AN INSULIN-RESPONSIVE GLUCOSE TRANSPORTER PROTEIN [J].

BIRNBAUM, MJ .

CELL, 1989, 57 (02) :305-315

[8] Transmembrane movement of exogenous long-chain fatty acids: Proteins, enzymes, and vectorial esterification [J].

Black, PN ;

DiRusso, CC .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2003, 67 (03) :454-+

[9] Role of fatty acids in the pathogenesis of insulin resistance and NIDDM [J].

Boden, G .

DIABETES, 1997, 46 (01) :3-10

[10] Plasmalemmal fatty acid transport is regulated in heart and skeletal muscle by contraction, insulin and leptin, and in obesity and diabetes [J].

Bonen, A ;

Benton, CR ;

Campbell, SE ;

Chabowski, A ;

Clarke, DC ;

Hang, XX ;

Glatz, JFC ;

Luiken, JJFP .

ACTA PHYSIOLOGICA SCANDINAVICA, 2003, 178 (04) :347-356

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