共 30 条
Sharing of a conserved haplotype suggests a susceptibility gene for multiple sclerosis at chromosome 17p11
被引:13
作者:

He, B
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Giedraitis, V
论文数: 0 引用数: 0
h-index: 0
机构:
Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Ligers, A
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Binzer, M
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Andersen, PM
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Forsgren, L
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Sandkuijl, LA
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden

Hillert, J
论文数: 0 引用数: 0
h-index: 0
机构: Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden
机构:
[1] Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden
[2] Karolinska Inst, Dept Med Biochem & Biophys, Div Matrix Biol, Stockholm, Sweden
[3] Univ Umea Hosp, Dept Neurol, S-90185 Umea, Sweden
[4] Erasmus Univ, Inst Clin Genet, Rotterdam, Netherlands
[5] Leiden Univ, Dept Human Genet, NL-2300 RA Leiden, Netherlands
关键词:
chromosome;
17p;
genomic screen;
haplotype sharing;
multiple sclerosis;
susceptibility gene;
D O I:
10.1038/sj.ejhg.5200802
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Multiple sclerosis (MS) is a chronic inflammatory disease resulting in demyelination in the central nervous system (CNS). Increasing evidence supports that genetic factors confer susceptibility to MS. One locus, the HLA complex (6p21), has been identified as important in MS, but no other loci have been clearly implicated, neither by a candidate gene approach, nor by a genomic screen strategy. Here, we studied a genetically isolated population in the northern-most part of Sweden, which demonstrates a high incidence of MS, using haplotype sharing analysis. Genealogical analysis demonstrated that 22 MS patients originate from a single common ancestral couple in the eighteenth century. Five affected individuals from four nuclear families were selected for an initial genomic screen with 390 microsatellite markers. Seven shared haplotypes in six different chromosomal regions were observed. After genotyping for these haplotypes with the same and additional markers in 15 MS patients and healthy relatives, some portion of a conserved haplotype spanning 10 cM at 17p11 was found to be shared by 12 of 15 affected individuals. The statistical analysis revealed a significant excess of transmission of alleles of three markers to affected individuals (P<0.05) by the transmission/disequilibrium test (TDT). An identical four-marker haplotype was shared by six of 15 patients (40%; P<0.01). Surprisingly, DR-typing revealed no significant sharing of the HLA region. In conclusion, our data suggests a novel susceptibility gene for MS in chromosome 17p11.
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收藏
页码:271 / 275
页数:5
相关论文
共 30 条
[1]
FAMILIAL CLUSTERING OF MULTIPLE-SCLEROSIS IN A NORTHERN SWEDISH RURAL DISTRICT
[J].
BINZER, M
;
FORSGREN, L
;
HOLMGREN, G
;
DRUGGE, U
;
FREDRIKSON, S
.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,
1994, 57 (04)
:497-499

BINZER, M
论文数: 0 引用数: 0
h-index: 0
机构: UMEA UNIV, DEPT CLIN GENET, UMEA, SWEDEN

FORSGREN, L
论文数: 0 引用数: 0
h-index: 0
机构: UMEA UNIV, DEPT CLIN GENET, UMEA, SWEDEN

HOLMGREN, G
论文数: 0 引用数: 0
h-index: 0
机构: UMEA UNIV, DEPT CLIN GENET, UMEA, SWEDEN

DRUGGE, U
论文数: 0 引用数: 0
h-index: 0
机构: UMEA UNIV, DEPT CLIN GENET, UMEA, SWEDEN

FREDRIKSON, S
论文数: 0 引用数: 0
h-index: 0
机构: UMEA UNIV, DEPT CLIN GENET, UMEA, SWEDEN
[2]
HLA-DR-DQ HAPLOTYPES DEFINED BY RESTRICTION FRAGMENT ANALYSIS - CORRELATION TO SEROLOGY
[J].
CARLSSON, B
;
WALLIN, J
;
BOHME, J
;
MOLLER, E
.
HUMAN IMMUNOLOGY,
1987, 20 (02)
:95-113

CARLSSON, B
论文数: 0 引用数: 0
h-index: 0
机构: HUDDINGE UNIV HOSP,KAROLINSKA HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN

WALLIN, J
论文数: 0 引用数: 0
h-index: 0
机构: HUDDINGE UNIV HOSP,KAROLINSKA HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN

BOHME, J
论文数: 0 引用数: 0
h-index: 0
机构: HUDDINGE UNIV HOSP,KAROLINSKA HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN

MOLLER, E
论文数: 0 引用数: 0
h-index: 0
机构: HUDDINGE UNIV HOSP,KAROLINSKA HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN
[3]
LINKAGE DISEQUILIBRIUM MAPPING OF A TYPE-1 DIABETES SUSCEPTIBILITY GENE (IDDM7) TO CHROMOSOME 2Q31-Q33
[J].
COPEMAN, JB
;
CUCCA, F
;
HEARNE, CM
;
CORNALL, RJ
;
REED, PW
;
RONNINGEN, KS
;
UNDLIEN, DE
;
NISTICO, L
;
BUZZETTI, R
;
TOSI, R
;
POCIOT, F
;
NERUP, J
;
CORNELIS, F
;
BARNETT, AH
;
BAIN, SC
;
TODD, JA
.
NATURE GENETICS,
1995, 9 (01)
:80-85

COPEMAN, JB
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

CUCCA, F
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

HEARNE, CM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

CORNALL, RJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

REED, PW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

RONNINGEN, KS
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

UNDLIEN, DE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

NISTICO, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

BUZZETTI, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

TOSI, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

POCIOT, F
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

NERUP, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

CORNELIS, F
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

BARNETT, AH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

BAIN, SC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

TODD, JA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND
[4]
Linkage disequilibrium mapping in isolated populations: The example of Finland revisited
[J].
De La Chapelle, A
;
Wright, FA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (21)
:12416-12423

De La Chapelle, A
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA

Wright, FA
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA
[5]
A comprehensive genetic map of the human genome based on 5,264 microsatellites
[J].
Dib, C
;
Faure, S
;
Fizames, C
;
Samson, D
;
Drouot, N
;
Vignal, A
;
Millasseau, P
;
Marc, S
;
Hazan, J
;
Seboun, E
;
Lathrop, M
;
Gyapay, G
;
Morissette, J
;
Weissenbach, J
.
NATURE,
1996, 380 (6570)
:152-154

Dib, C
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Faure, S
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Fizames, C
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Samson, D
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Drouot, N
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Vignal, A
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Millasseau, P
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Marc, S
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Hazan, J
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Seboun, E
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Lathrop, M
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Gyapay, G
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Morissette, J
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE

Weissenbach, J
论文数: 0 引用数: 0
h-index: 0
机构: GENETHON SA,F-91000 EVRY,FRANCE
[6]
SETS OF SHORT TANDEM REPEAT POLYMORPHISMS FOR EFFICIENT LINKAGE SCREENING OF THE HUMAN GENOME
[J].
DUBOVSKY, J
;
SHEFFIELD, VC
;
DUYK, GM
;
WEBER, JL
.
HUMAN MOLECULAR GENETICS,
1995, 4 (03)
:449-452

DUBOVSKY, J
论文数: 0 引用数: 0
h-index: 0
机构: MARSHFIELD MED RES FDN,CTR GENET MED,MARSHFIELD,WI 54449

SHEFFIELD, VC
论文数: 0 引用数: 0
h-index: 0
机构: MARSHFIELD MED RES FDN,CTR GENET MED,MARSHFIELD,WI 54449

DUYK, GM
论文数: 0 引用数: 0
h-index: 0
机构: MARSHFIELD MED RES FDN,CTR GENET MED,MARSHFIELD,WI 54449

WEBER, JL
论文数: 0 引用数: 0
h-index: 0
机构: MARSHFIELD MED RES FDN,CTR GENET MED,MARSHFIELD,WI 54449
[7]
Genome scanning for segments shared identical by descent among distant relatives in isolated populations
[J].
Durham, LK
;
Feingold, E
.
AMERICAN JOURNAL OF HUMAN GENETICS,
1997, 61 (04)
:830-842

Durham, LK
论文数: 0 引用数: 0
h-index: 0
机构:
EMORY UNIV,ROLLINS SCH PUBL HLTH,DEPT BIOSTAT,ATLANTA,GA 30322 EMORY UNIV,ROLLINS SCH PUBL HLTH,DEPT BIOSTAT,ATLANTA,GA 30322

Feingold, E
论文数: 0 引用数: 0
h-index: 0
机构:
EMORY UNIV,ROLLINS SCH PUBL HLTH,DEPT BIOSTAT,ATLANTA,GA 30322 EMORY UNIV,ROLLINS SCH PUBL HLTH,DEPT BIOSTAT,ATLANTA,GA 30322
[8]
THE ROLE OF GENETIC-FACTORS IN MULTIPLE-SCLEROSIS SUSCEPTIBILITY
[J].
EBERS, GC
;
SADOVNICK, AD
.
JOURNAL OF NEUROIMMUNOLOGY,
1994, 54 (1-2)
:1-17

EBERS, GC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV WESTERN ONTARIO, DEPT CLIN NEUROL SCI, LONDON, ON, CANADA

SADOVNICK, AD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV WESTERN ONTARIO, DEPT CLIN NEUROL SCI, LONDON, ON, CANADA
[9]
A full genome search in multiple sclerosis
[J].
Ebers, GC
;
Kukay, K
;
Bulman, DE
;
Sadovnick, AD
;
Rice, G
;
Anderson, C
;
Armstrong, H
;
Cousin, K
;
Bell, RB
;
Hader, W
;
Paty, DW
;
Hashimoto, S
;
Oger, J
;
Duquette, P
;
Warren, S
;
Gray, T
;
OConnor, P
;
Nath, A
;
Auty, A
;
Metz, L
;
Francis, G
;
Paulseth, JE
;
Murray, TJ
;
PrysePhillips, W
;
Nelson, R
;
Freedman, M
;
Brunet, D
;
Bouchard, JP
;
Hinds, D
;
Risch, N
.
NATURE GENETICS,
1996, 13 (04)
:472-476

Ebers, GC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Kukay, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Bulman, DE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Sadovnick, AD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Rice, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Anderson, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Armstrong, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Cousin, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Bell, RB
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Hader, W
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Paty, DW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Hashimoto, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Oger, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Duquette, P
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Warren, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Gray, T
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

OConnor, P
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Nath, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Auty, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Metz, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Francis, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Paulseth, JE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Murray, TJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

PrysePhillips, W
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Nelson, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Freedman, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Brunet, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Bouchard, JP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Hinds, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

Risch, N
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA
[10]
A GENETIC-BASIS FOR FAMILIAL AGGREGATION IN MULTIPLE-SCLEROSIS
[J].
EBERS, GC
;
SADOVNICK, AD
;
RISCH, NJ
;
BULMAN, D
;
RICE, GPA
;
HASHIMOTO, SA
;
PATY, D
;
OGER, JJF
;
METZ, L
;
BELL, R
;
WARREN, S
;
HADER, W
;
AUTY, T
;
NATH, A
;
GRAY, T
;
OCONNOR, P
;
NELSON, R
;
FREEDMAN, M
;
BRUNET, D
;
PAULSETH, R
;
FRANCIS, G
;
DUQUETTE, P
;
MURRAY, TJ
;
BAHN, V
;
PRYSEPHILLIPS, W
.
NATURE,
1995, 377 (6545)
:150-151

EBERS, GC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC V6T 1W5,CANADA

SADOVNICK, AD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC V6T 1W5,CANADA

RISCH, NJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC V6T 1W5,CANADA

BULMAN, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC V6T 1W5,CANADA

RICE, GPA
论文数: 0 引用数: 0
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HASHIMOTO, SA
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PATY, D
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OGER, JJF
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METZ, L
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BELL, R
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WARREN, S
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HADER, W
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AUTY, T
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NATH, A
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GRAY, T
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OCONNOR, P
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NELSON, R
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FREEDMAN, M
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BRUNET, D
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PAULSETH, R
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FRANCIS, G
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DUQUETTE, P
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MURRAY, TJ
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BAHN, V
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PRYSEPHILLIPS, W
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