Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

被引:444
作者
Wendling, F
Bartolomei, F
Bellanger, JJ
Chauvel, P
机构
[1] Univ Rennes 1, INSERM, Lab Traitement Signal & Image, F-35042 Rennes, France
[2] Univ Mediterranee, INSERM, Lab Neurophysiol & Neuropsychol, F-13385 Marseille 5, France
关键词
dis-inhibition; gamma band activity; interneuronal circuits; intracerebral EEG;
D O I
10.1046/j.1460-9568.2002.01985.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This paper focuses on high-frequency (gamma band) EEG activity, the most characteristic electrophysiological pattern in focal seizures of human epilepsy. It starts with recent hypotheses about: (i) the behaviour of inhibitory interneurons in hippocampal or neocortical networks in the generation of gamma frequency oscillations; (ii) the nonuniform alteration of GABAergic inhibition in experimental epilepsy (reduced dendritic inhibition and increased somatic inhibition); and (iii) the possible depression of GABA(A,fast) circuit activity by GABA(A,slow) inhibitory postsynaptic currents. In particular, these hypotheses are introduced in a new computational macroscopic model of EEG activity that includes a physiologically relevant fast inhibitory feedback loop. Results show that strikingly realistic activity is produced by the model when compared to real EEG signals recorded with intracerebral electrodes. They show that, in the model, the transition from interictal to fast ictal activity is explained by the impairment of dendritic inhibition.
引用
收藏
页码:1499 / 1508
页数:10
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