Gold(I)-catalyzed intramolecular hydroamination of alkyne with trichloroacetimidates

被引：129

作者：

Kang, Ji-Eun ^{[1
]}

Kim, Hak-Beom ^{[1
]}

Lee, Jin-Woo ^{[1
]}

Shin, Seunghoon ^{[1
]}

机构：

[1] Hanyang Univ, Dept Chem, Seoul 133791, South Korea

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1021/ol061307r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A study on the gold (I)-catalyzed intramolecular hydroamination of trichloroacetimidates derived from propargyl and homopropargyl alcohols is described. In the presence of 2 - 5 mol % of cationic Au(I) complex, a variety of trichloroacetimidates undergo efficient hydroamination under an exceptionally mild condition. An orthogonality of the current catalytic protocol with those using a stoichiometric electrophile as well as a preliminary synthetic application as a stable precursor of 2-acylamino-1,3-diene has been demonstrated.

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页码：3537 / 3540

页数：4

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