Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities

被引：38

作者：

Xu, Xiaoting ^{[1
,2
]}

Bai, Hong ^{[1
]}

Zhou, Ling ^{[1
]}

Deng, Zhipeng ^{[1
]}

Zhong, Hao ^{[1
]}

Wu, Zhongyu ^{[1
]}

Yao, Qingqiang ^{[1
]}

机构：

[1] Shandong Acad Med Sci, Inst Mat Med, Jinan 250062, Shandong, Peoples R China

[2] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan 250062, Shandong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 09期

关键词：

Hemsleya penxianensis; Cucurbitane triterpenoids; Cytotoxic activities; GLYCOSIDES;

D O I：

10.1016/j.bmcl.2014.03.027

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-beta-D-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1-6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human cancer cell lines, with IC50 values in the low microgram range. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2159 / 2162

页数：4

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