Cucurbitacins and cucurbitane glycosides: structures and biological activities

被引：500

作者：

Chen, JC

Chiu, MH ^{[1
]}

Nie, RL

Cordell, GA

Qiu, SX

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 65024, Peoples R China

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[3] Washington Univ, Dept Chem, St Louis, MO 63017 USA

来源：

NATURAL PRODUCT REPORTS | 2005年 / 22卷 / 03期

关键词：

D O I：

10.1039/b418841c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cueurbitane nucleus skeleton, namely, 19-(10 -> 9 beta)-abeo-10 alpha-lanost-5-ene (also known as 9 beta-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.

引用

页码：386 / 399

页数：14

共 157 条

[1] FEVICORDIN-A AND FEVICORDIN-A GLUCOSIDE, NOVEL NORCUCURBITACINS FROM FEVILLEA-CORDIFOLIA [J].

ACHENBACH, H ;

HEFTERBUBL, U ;

CONSTENLA, MA .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (06) :441-442

[2] CONSTITUENTS OF TROPICAL MEDICINAL-PLANTS .59. CONSTITUENTS OF FEVILLEA-CORDIFOLIA - NEW NORCUCURBITACIN AND CUCURBITACIN GLYCOSIDES [J].

ACHENBACH, H ;

WAIBEL, R ;

HEFTERBUBL, U ;

CONSTENLA, MA .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (09) :1506-1519

[3] CUCURBITANES AND CUCURBITANE-TYPE GLYCOSIDES FROM IBERVILLEA-SONORAE [J].

ACHENBACH, H ;

HORN, K ;

DOMINGUEZ, XA ;

ROMBOLD, C ;

LOPEZ, EGG .

PHYTOCHEMISTRY, 1993, 33 (02) :437-445

[4] Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum [J].

Afifi, MS ;

Ross, SA ;

elSohly, MA ;

Naeem, ZE ;

Halaweish, FT .

JOURNAL OF CHEMICAL ECOLOGY, 1999, 25 (04) :847-859

[5] Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium [J].

Agil, A ;

Miró, M ;

Jimenez, J ;

Aneiros, J ;

Caracuel, MD ;

García-Granados, A ;

Navarro, MC .

PLANTA MEDICA, 1999, 65 (07) :673-675

[6]

Ahmad A, 1999, PLANTA MED, V65, P673

[7] 7-OXO-10-ALPHA-CUCURBITADIENOL FROM THE SEEDS OF TRICHOSANTHES KIRILOWII AND ITS ANTIINFLAMMATORY EFFECT [J].

AKIHISA, T ;

YASUKAWA, K ;

KIMURA, Y ;

TAKIDO, M ;

KOKKE, WCMC ;

TAMURA, T .

PHYTOCHEMISTRY, 1994, 36 (01) :153-157

[8] A CYTO-TOXIC DEOXOCUCURBITACIN FROM DESFONTAINIA-SPINOSA [J].

AMONKAR, AA ;

MCCLOUD, TG ;

CHANG, CJ ;

SAENZRENAULD, JA ;

CASSADY, JM .

PHYTOCHEMISTRY, 1985, 24 (08) :1803-1805

[9]

ATTAURRAHMAN VU, 1973, PHYTOCHEMISTRY, V12, P2741

[10] Role of cucurbitacin C in resistance to spider mite (Tetranychus urticae) in cucumber (Cucumis sativus L.) [J].

Balkema-Boomstra, AG ;

Zijlstra, S ;

Verstappen, FWA ;

Inggamer, H ;

Mercke, PE ;

Jongsma, MA ;

Bouwmeester, HJ .

JOURNAL OF CHEMICAL ECOLOGY, 2003, 29 (01) :225-235

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