Fully stereocontrolled total syntheses of (-)-cylindricine C and (-)-2-epicylindricine C: A departure in sulfonamide chemistry

被引：121

作者：

Canesi, S

Bouchu, D

Ciufolini, MA

机构：

[1] Univ Lyon 1, CNRS, UMR 5181, Lab Synth & Methodol Organ, F-69622 Villeurbanne, France

[2] Ecole Super Chim Phys & Elect, F-69622 Villeurbanne, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 33期

关键词：

antitumor agents; cyclization; spiro compounds; sulfonamides; total synthesis;

D O I：

10.1002/anie.200460178

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A common intermediate was used in the total syntheses of (-)-cylindricine C and (-)-2-epicylindricine C (see picture) in a process that involves the initial oxidative spirocyclization of a phenolic sulfonamide. The remainder of the molecules is constructed through interesting sulfonamide chemistry.

引用

页码：4336 / 4338

页数：3

共 31 条

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[2]

2-1

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