Nonviral Methods for siRNA Delivery

被引：195

作者：

Gao, Kun ^{[2
]}

Huang, Leaf ^{[1
]}

机构：

[1] Univ N Carolina, Div Mol Pharmaceut, Sch Pharm, Chapel Hill, NC 27599 USA

[2] Xi An Jiao Tong Univ, Key Lab Biomed Informat Engn, Minist Educ, Sch Life Sci & Technol, Xian 710049, Peoples R China

来源：

MOLECULAR PHARMACEUTICS | 2009年 / 6卷 / 03期

关键词：

RNA interference; small interfering RNA; delivery; nanoparticles; SMALL INTERFERING RNA; INHIBITS TUMOR-GROWTH; IN-VIVO DELIVERY; SYSTEMIC DELIVERY; GENE-EXPRESSION; DRUG-DELIVERY; PAMAM DENDRIMERS; SYNTHETIC SIRNAS; VITRO; LIPOSOMES;

D O I：

10.1021/mp800134q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

RNA interference (RNAi) as a mechanism to selectively degrade mRNA (mRNA) expression has emerged as a potential novel approach for drug target validation and the study of functional genomics. Small interfering RNAs (siRNA) therapeutics has developed rapidly and already there are clinical trials ongoing or planned. Although other challenges remain, delivery strategies for siRNA become the main hurdle that must be resolved prior to the full-scale clinical development of siRNA therapeutics. This review provides an overview of the current delivery strategies for synthetic siRNA, focusing on the targeted, self-assembled nanoparticles which show potential to become a useful and efficient tool in cancer therapy.

引用

页码：651 / 658

页数：8

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