Design and fabrication of integrated passive valves and pumps for flexible polymer 3-dimensional microfluidic systems

被引：132

作者：

Jeon, NL ^{[1
]}

Chiu, DT ^{[1
]}

Wargo, CJ ^{[1
]}

Wu, HK ^{[1
]}

Choi, IS ^{[1
]}

Anderson, JR ^{[1
]}

Whitesides, GM ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

BIOMEDICAL MICRODEVICES | 2002年 / 4卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

microfluidies; valves; PDMS;

D O I：

10.1023/A:1014683114796

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper describes the fabrication of flexible, polymeric 3-dimensional microfluidic systems with integrated check valves (flap and diaphragm valves) and a pump by stacking patterned poly(dimethylsiloxane) (PDMS) layers containing microchannels and vias. We describe this procedure for fabricating, manipulating, and bonding of PDMS membranes and bas-relief plates into multilayer microfluidic devices. The fabrication and demonstration of integrated check valves and a pump in a prototype polymer 3-dimensional microfluidic system is a step toward practical realization of all-polymer, flexible, low-cost, disposable microfluidic devices for biochemical applications.

引用

页码：117 / 121

页数：5

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