Sexually dimorphic gray matter volume reduction in patients with panic disorder

被引:85
作者
Asami, Takeshi [1 ]
Yamasue, Hidenori [3 ]
Hayano, Fumi [1 ]
Nakamura, Motoaki [1 ]
Uehara, Kumi [1 ]
Otsuka, Tatsui [1 ]
Roppongi, Tomohide [1 ]
Nihashi, Namiko [1 ]
Inoue, Tomio [2 ]
Hirayasu, Yoshio [1 ]
机构
[1] Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[2] Yokohama City Univ, Sch Med, Dept Radiol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[3] Univ Tokyo, Dept Neuropsychiat, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan
关键词
MRI; VBM; Prefrontal cortex; Amygdala; Sex difference; TEMPORAL-LOBE VOLUME; BRAIN; CORTEX; ATTACK; WOMEN; SEX;
D O I
10.1016/j.pscychresns.2008.10.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
While clinical features of panic disorder show significant sexual dimorphism, previous structural MRI studies have not sufficiently controlled for sex when looking at regional brain abnormalities in panic disorder. Using optimized voxel-based morphometry (VBM), regional gray matter volume was compared between 24 patients (male/female: 9/15) with panic disorder and 24 healthy subjects matched for age and sex. Significant gray matter volume reductions were found in the bilateral dorsomedial and right ventromedial prefrontal cortices, right amygdala, anterior cingulate cortex, bilateral insular cortex, occipitotemporal gyrus and left cerebellar vermis in the patients compared with the controls. Among these regions, the VBM revealed significant sexual dimorphism: volume reduction in the right amygdala and the bilateral insular cortex was significantly greater in the males, while reduction in the right superior temporal gyrus was greater in females. Furthermore, a significant reduction in the dorsolateral and ventrolateral prefrontal cortices, thalamus, and parietal cortex was specific to the female patients. The present study demonstrated the morphological changes in extensive brain regions of patients with panic disorder compared with the sex-matched controls. The current results further suggested that the sexually dimorphic clinical phenotypes of panic disorder might have a neurobiological background even at the structural level of the brain. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:128 / 134
页数:7
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