Harnessing actin dynamics for clathrin-mediated endocytosis

被引:571
作者
Kaksonen, Marko [1 ]
Toret, Christopher P. [1 ]
Drubin, David G. [1 ]
机构
[1] Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94720 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrm1940
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells. A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane - namely endocytosis - has recently been established. Live-cell imaging studies are shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.
引用
收藏
页码:404 / 414
页数:11
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