Telomerase, mitochondria and oxidative stress

被引：117

作者：

Saretzki, Gabriele ^{[1
]}

机构：

[1] Biosci Ctr, Int Ctr Life, Inst Ageing & Hlth, Crucible Lab, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

EXPERIMENTAL GERONTOLOGY | 2009年 / 44卷 / 08期

关键词：

Telomerase; Oxidative stress; Telomere-independent function; hTERT; Mitochondria; REVERSE-TRANSCRIPTASE; CATALYTIC SUBUNIT; HUMAN FIBROBLASTS; NUCLEAR EXPORT; HTERT PROTEIN; DNA-DAMAGE; LIFE-SPAN; CELLS; EXPRESSION; INHIBITION;

D O I：

10.1016/j.exger.2009.05.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Telomerase plays an important role in cellular proliferation capacity and survival under conditions of stress. A large part of this protective function is due to telomere capping and maintenance. Thus it contributes to cellular immortality in stem cells and cancer. Recently, evidence has accumulated that telomerase can contribute to cell survival and stress resistance in a largely telomere-independent manner. Telomerase has been shown to shuttle dynamically between different cellular locations. Under increased oxidative stress telomerase is excluded from the nucleus and can be found within the mitochondria. This phenotype correlates with decreased oxidative stress within telomerase expressing cells and improved mitochondrial function by currently largely unknown mechanisms. Our data suggest that mitochondrial protection could be an important non-canonical function for telomerase in cell survival and ageing. This review summarises briefly our knowledge about extra-telomeric functions of telomerase and discusses the potential significance of its mitochondrial localisation. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：485 / 492

页数：8

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