Oxygen and Pt(ll) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor

被引：257

作者：

Xu, Shuting ^{[1
]}

Zhu, Xinyuan ^{[1
]}

Zhang, Chuan ^{[1
]}

Huang, Wei ^{[1
]}

Zhou, Yongfeng ^{[1
]}

Yan, Deyue ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; HYPERBARIC-OXYGEN; CANCER; NANOPARTICLES; CHEMOTHERAPY; METASTASIS; EFFICIENT; POTENT;

D O I：

10.1038/s41467-018-04318-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Cancer cells in hypoxic tumors are remarkably resistant to photodynamic therapy. Here, we hypothesize that an oxygen and Pt(ll) self-generating multifunctional nanocomposite could reverse the hypoxia-triggered PDT resistance. The nanocomposite contains Pt(IV) and chlorin e6, in which upconversion nanoparticles are loaded to convert 980 nm near-infrared light into 365 nm and 660 nm emissions. Upon accumulation at the tumor site, a 980 nm laser is used to trigger the nanocomposite to generate O-2 for consumption in the PDT process and to produce cytotoxic reactive oxygen species. The composite also releases active Pt(ll) for synergistic photo-chemo therapy to enhance antitumor efficiency. The oxygen and Pt(ll) self-generating prodrug is shown to have high potential to inhibit tumors out of the range of UV light, to overcome the hypoxia-triggered PDT resistance and significantly improve anticancer efficacy by the synergistic PDT-chemotherapy.

引用

页数：9

共 30 条

[1]

Exploiting tumour hypoxia in cancer treatment [J].