Fluorescent Multiblock π-Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting

被引：86

作者：

Ahmed, Eilaf ^{[1
,2
]}

Morton, Stephen W. ^{[3
]}

Hammond, Paula T. ^{[3
]}

Swager, Timothy M. ^{[1
,2
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 32期

基金：

美国国家科学基金会;

关键词：

block copolymers; conjugated polymers; fluorescent bioimaging; nanoparticles; tumor targeting; NEAR-INFRARED WINDOW; DRUG-DELIVERY; CARBON NANOTUBES; QUANTUM DOTS; CANCER; BIODISTRIBUTION; DESIGN; DENDRIMERS;

D O I：

10.1002/adma.201301656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly fluorescent multiblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioimaging and in vivo tumor targeting. The targeted nanoparticles were preferentially localized in tumor cells in vivo, thereby illustrating their potential for diagnostic and therapeutic applications. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4504 / 4510

页数：7

共 41 条

[11]

Huynh N. T., 2010, NANOMEDICINE, V5, P1743

[12] Delivering nanomedicine to solid tumors [J].

Jain, Rakesh K. ;

Stylianopoulos, Triantafyllos .

NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (11) :653-664

[13] Challenges facing colloidal delivery systems: From synthesis to the clinic [J].

Johnston, Angus P. R. ;

Such, Georgina K. ;

Ng, Sher Leen ;

Caruso, Frank .

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2011, 16 (03) :171-181

[14] Block copolymer micelles for drug delivery: design, characterization and biological significance [J].

Kataoka, K ;

Harada, A ;

Nagasaki, Y .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :113-131

[15] Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery Across Biological Barriers [J].

Kievit, Forrest M. ;

Zhang, Miqin .

ADVANCED MATERIALS, 2011, 23 (36) :H217-H247

[16] Use of a folate-PPE conjugate to image cancer cells in vitro [J].

Kim, Ik-Bum ;

Shin, Heungsoo ;

Garcia, Andres J. ;

Bunz, Uwe H. F. .

BIOCONJUGATE CHEMISTRY, 2007, 18 (03) :815-820

[17] Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping [J].

Kim, S ;

Lim, YT ;

Soltesz, EG ;

De Grand, AM ;

Lee, J ;

Nakayama, A ;

Parker, JA ;

Mihaljevic, T ;

Laurence, RG ;

Dor, DM ;

Cohn, LH ;

Bawendi, MG ;

Frangioni, JV .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :93-97

[18] Conjugated polymer nanoparticles for biomedical in vivo imaging [J].

Kim, Sehoon ;

Lim, Chang-Keun ;

Na, Jinhee ;

Lee, Yong-Deok ;

Kim, Kwangmeyung ;

Choi, Kuiwon ;

Leary, James F. ;

Kwon, Ick Chan .

CHEMICAL COMMUNICATIONS, 2010, 46 (10) :1617-1619

[19] Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives [J].

Knop, Katrin ;

Hoogenboom, Richard ;

Fischer, Dagmar ;

Schubert, Ulrich S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (36) :6288-6308

[20] Designing dendrimers for biological applications [J].

Lee, CC ;

MacKay, JA ;

Fréchet, JMJ ;

Szoka, FC .

NATURE BIOTECHNOLOGY, 2005, 23 (12) :1517-1526

← 1 2 3 4 5 →