Fluorescent Multiblock π-Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting

被引：86

作者：

Ahmed, Eilaf ^{[1
,2
]}

Morton, Stephen W. ^{[3
]}

Hammond, Paula T. ^{[3
]}

Swager, Timothy M. ^{[1
,2
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 32期

基金：

美国国家科学基金会;

关键词：

block copolymers; conjugated polymers; fluorescent bioimaging; nanoparticles; tumor targeting; NEAR-INFRARED WINDOW; DRUG-DELIVERY; CARBON NANOTUBES; QUANTUM DOTS; CANCER; BIODISTRIBUTION; DESIGN; DENDRIMERS;

D O I：

10.1002/adma.201301656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly fluorescent multiblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioimaging and in vivo tumor targeting. The targeted nanoparticles were preferentially localized in tumor cells in vivo, thereby illustrating their potential for diagnostic and therapeutic applications. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4504 / 4510

页数：7