Roles of postsynaptic density-95/synapse-associated protein 90 and its interacting proteins in the organization of synapses

被引:46
作者
Hata, Y
Takai, Y
机构
[1] Japan Sci & Technol Corp, ERATO, Takai Biotimer Project, Nishi Ku, Kobe, Hyogo 6512241, Japan
[2] Tokyo Med & Dent Univ, Dept Biochem, Bunkyo Ku, Tokyo 1138510, Japan
[3] Osaka Univ, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan
关键词
PSD-95/SAP90; scaffolding protein; synaptic plasticity; glutamate receptor;
D O I
10.1007/s000180050445
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Synapses are central stages for neurotransmission: Neurotransmitters are released from the presynaptic membrane of one neuron, and bind to the receptors accumulated at the postsynaptic membrane, followed by the activation of the other neuron. The strength of a synapse is modified depending on the history: of:the previous neurotransmissions. This property is called synaptic plasticity and is implicated in learning and memory. Synapses contain not only the components essential for neurotransmission but also the signalling molecules involved in synaptic plasticity. The elucidation of the molecular structures of synapses is one of the: key steps to understand the mechanism of learning and memory. Recent studies have revealed postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90 as a core component in the architecture of synapses. In this review, we summarize up-to-date information:about PSD-95/SAP90 and its interacting proteins, and the organization of synapses orchestrated by PSD-95/SAP90.
引用
收藏
页码:461 / 472
页数:12
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