Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3

被引：22

作者：

Aoh, Yu ^{[1
]}

Hsiao, Han-Jun ^{[1
]}

Lu, Ming-Kuei ^{[1
,2
]}

Macerollo, Antonella ^{[3
]}

Huang, Hui-Chun ^{[2
]}

Hamada, Masashi ^{[4
]}

Tsai, Chon-Haw ^{[1
,2
]}

Chen, Jui-Cheng ^{[1
,2
,5
]}

机构：

[1] China Med Univ Hosp, Dept Neurol, Neurosci Lab, Taichung, Taiwan

[2] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan

[3] UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England

[4] Univ Tokyo, Dept Neurol, Grad Sch Med, Tokyo, Japan

[5] China Med Univ, Dept Neurol, Hsinchu Hosp, Hsinchu, Taiwan

来源：

FRONTIERS IN NEUROLOGY | 2019年 / 10卷

关键词：

ERD; ERS; cerebellar ataxia; SCA3; motor control; MACHADO-JOSEPH-DISEASE; BETA-SYNCHRONIZATION; CORTICAL POTENTIALS; MOVEMENT; OSCILLATIONS; INVOLVEMENT; ACTIVATION; DYNAMICS; ERD/ERS; CORTEX;

D O I：

10.3389/fneur.2019.00822

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patients with SCA3. Methods: We assessed ERD/ERS of self-paced voluntary hand movements in 15 patients with genetically proven SCA3 in comparison with healthy controls. Results: In ERS, a significant interaction effect between group, frequency, and period (F = 1.591; p = 0.005; rho l = 0.86) was observed. The post-hoc two-tailed independent t-test showed significant differences in high beta and low beta ERS. By contrast, in ERD, no apparent differences were observed in the pattern of patients with SCA3 in comparison with healthy controls (F = 1.01; p = 0.442). Conclusion: The study revealed a decreased ERS in patients with SCA3, especially at the frequency of 20-30 Hz. This study elucidates the significant role of cerebellum in motor control.

引用

页数：9

共 36 条

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