Organocatalytic peroxy-asymmetric allylic alkylation

被引：65

作者：

Feng, Xin ^{[1
]}

Yuan, Yu-Qing ^{[2
]}

Cui, Hai-Lei ^{[1
]}

Jiang, Kun ^{[1
]}

Chen, Ying-Chun ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Dept Med Chem,W China Sch Pharm, Chengdu 610041, Peoples R China

[2] Third Hosp Chengdu, Chengdu, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 18期

基金：

中国国家自然科学基金;

关键词：

BAYLIS-HILLMAN REACTION; CHIRAL IONIC LIQUIDS; KINETIC RESOLUTION; ENANTIOSELECTIVE SYNTHESIS; GAMMA-BUTENOLIDES; CATALYZED BAYLIS; ALDOL REACTION; CONSTRUCTION; SUBSTITUTION; ACETATES;

D O I：

10.1039/b912110b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The peroxy-asymmetric allylic alkylation of hydroperoxyalkanes with Morita-Baylis-Hillman carbonates was catalysed by modified cinchona alkaloids (up to 93% ee), from which chiral alpha-methylene-beta-hydroxy esters could be efficiently derived.

引用

页码：3660 / 3662

页数：3