Magnetic resonance support vector machine discriminates between Parkinson disease and progressive supranuclear palsy

被引：55

作者：

Cherubini, Andrea ^{[1
]}

Morelli, Maurizio ^{[2
]}

Nistico, Rita ^{[1
]}

Salsone, Maria ^{[2
]}

Arabia, Gennarina ^{[2
]}

Vasta, Roberta ^{[1
]}

Augimeri, Antonio ^{[1
]}

Caligiuri, Maria Eugenia ^{[1
]}

Quattrone, Aldo ^{[1
,2
]}

机构：

[1] CNR, Neuroimaging Res Unit, Inst Neurol Sci, Catanzaro, Italy

[2] Magna Graecia Univ Catanzaro, Inst Neurol, Catanzaro, Italy

来源：

MOVEMENT DISORDERS | 2014年 / 29卷 / 02期

关键词：

computer-aided diagnosis; support vector machines; progressive supranuclear palsy; diffusion tensor imaging; DIAGNOSTIC-CRITERIA; ACCURACY;

D O I：

10.1002/mds.25737

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background The aim of the current study was to distinguish patients with Parkinson disease (PD) from those with progressive supranuclear palsy (PSP) at the individual level using pattern recognition of magnetic resonance imaging data. Methods We combined diffusion tensor imaging and voxel-based morphometry in a support vector machine algorithm to evaluate 21 patients with PSP and 57 patients with PD. Results The automated algorithm correctly distinguished patients who had PD from those who had PSP with 100% accuracy. This accuracy value was obtained when white matter atrophy was considered. Diffusion parameters combined with gray matter atrophy exhibited 90% sensitivity and 96% specificity. Conclusions Our findings demonstrate that automated pattern recognition can help distinguish patients with PSP from those with PD on an individual basis. (c) 2013 International Parkinson and Movement Disorder Society

引用

页码：266 / 269

页数：4

共 15 条

[1]

LIBSVM: A Library for Support Vector Machines [J].

Chang, Chih-Chung ;

Lin, Chih-Jen .

ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY, 2011, 2 (03)

[2]

Individual Voxel-Based Subtype Prediction can Differentiate Progressive Supranuclear Palsy from Idiopathic Parkinson Syndrome and Healthy Controls [J].

Focke, Niels K. ;

Helms, Gunther ;

Scheewe, Sebstian ;

Pantel, Pia M. ;

Bachmann, Cornelius G. ;

Dechent, Peter ;

Ebentheuer, Jens ;

Mohr, Alexander ;

Paulus, Walter ;

Trenkwalder, Claudia .

HUMAN BRAIN MAPPING, 2011, 32 (11) :1905-1915

[3]

Diagnostic criteria for Parkinson disease [J].

Gelb, DJ ;

Oliver, E ;

Gilman, S .

ARCHIVES OF NEUROLOGY, 1999, 56 (01) :33-39

[4]

Individual Detection of Patients with Parkinson Disease using Support Vector Machine Analysis of Diffusion Tensor Imaging Data: Initial Results [J].

Haller, S. ;

Badoud, S. ;

Nguyen, D. ;

Garibotto, V. ;

Lovblad, K. O. ;

Burkhard, P. R. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2012, 33 (11) :2123-2128

[5]

The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service [J].

Hughes, AJ ;

Daniel, SE ;

Ben-Shlomo, Y ;

Lees, AJ .

BRAIN, 2002, 125 :861-870

[6]

FSL [J].

Jenkinson, Mark ;

Beckmann, Christian F. ;

Behrens, Timothy Ej. ;

Woolrich, Mark W. ;

Smith, Stephen M. .

NEUROIMAGE, 2012, 62 (02) :782-790

[7]

Diagnostic neuroimaging across diseases [J].

Kloeppel, Stefan ;

Abdulkadir, Ahmed ;

Jack, Clifford R., Jr. ;

Koutsouleris, Nikolaos ;

Mourao-Miranda, Janaina ;

Vemuri, Prashanthi .

NEUROIMAGE, 2012, 61 (02) :457-463

[8]

SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders [J].

Litvan, I ;

Bhatia, KP ;

Burn, DJ ;

Goetz, CG ;

Lang, AE ;

McKeith, I ;

Quinn, N ;

Sethi, KD ;

Shults, C ;

Wenning, GK .

MOVEMENT DISORDERS, 2003, 18 (05) :467-486

[9]

Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop [J].

Litvan, I ;

Agid, Y ;

Calne, D ;

Campbell, G ;

Dubois, B ;

Duvoisin, RC ;

Goetz, CG ;

Golbe, LI ;

Grafman, J ;

Growdon, JH ;

Hallett, M ;

Jankovic, J ;

Quinn, NP ;

Tolosa, E ;

Zee, DS ;

Chase, TN ;

FitzGibbon, EJ ;

Hall, Z ;

Juncos, J ;

Nelson, KB ;

Oliver, E ;

Pramstaller, P ;

Reich, SG ;

Verny, M .

NEUROLOGY, 1996, 47 (01) :1-9

[10]

Accuracy of Magnetic Resonance Parkinsonism Index for Differentiation of Progressive Supranuclear Palsy from Probable or Possible Parkinson Disease [J].

Morelli, Maurizio ;

Arabia, Gennarina ;

Salsone, Maria ;

Novellino, Fabiana ;

Giofre, Laura ;

Paletta, Rosina ;

Messina, Demetrio ;

Nicoletti, Giuseppe ;

Condino, Francesca ;

Gallo, Olivier ;

Lanza, Pierluigi ;

Quattrone, Aldo .

MOVEMENT DISORDERS, 2011, 26 (03) :527-533

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