Myometrial maxi-K channel β1 subunit modulation during pregnancy and after 17β-estradiol stimulation

被引：24

作者：

Benkusky, NA ^{[1
]}

Korovkina, VP ^{[1
]}

Brainard, AM ^{[1
]}

England, SK ^{[1
]}

机构：

[1] Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA

来源：

FEBS LETTERS | 2002年 / 524卷 / 1-3期

关键词：

mouse; uterus; maxi-K; beta subunit; gestation; estrogen; progesterone;

D O I：

10.1016/S0014-5793(02)03011-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myometrial maxi-K channels are modulated by beta subunits. We aimed to determine whether beta subunits are modulated to affect uterine excitability during gestation. RNase protection analyses revealed that mouse beta1 subunit transcripts are regulated during gestation with peak expression at day 14 of pregnancy. Immunohistochemical analysis indicates an increase of this subunit during gestation. Upregulation of the beta1 transcript occurs with 4-day exposure to 17beta-estradiol but not progesterone, and acute estradiol exposure has no effect on beta1 transcript expression. These findings verify that beta1 subunit transcript is regulated in mouse myometrium during gestation and estrogens may contribute to this increase. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：97 / 102

页数：6

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