Homologous recombination-mediated double-strand break repair

被引：155

作者：

Wyman, C

Ristic, D

Kanaar, R

机构：

[1] Erasmus Med Ctr Daniel, Dept Radiat Oncol, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

homologous; recombination; DNA double-strand break; genome; prokaryotes; eukaryotes; Holliday junction;

D O I：

10.1016/j.dnarep.2004.03.037

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Exchange of DNA strands between homologous DNA molecules via recombination ensures accurate genome duplication and preservation of genome integrity. Biochemical studies have provided insights into the molecular mechanisms by which homologous recombination proteins perform these essential tasks. More recent cell biological experiments are addressing the behavior of homologous recombination proteins in cells. The challenge ahead is to uncover the relationship between the individual biochemical activities of homologous recombination proteins and their coordinated action in the context of the living cell. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：827 / 833

页数：7

相关论文

共 45 条

[21] Initiation of genetic recombination and recombination-dependent replication [J].

Kowalczykowski, SC .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (04) :156-165

[22] Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage [J].

Lee, SE ;

Moore, JK ;

Holmes, A ;

Umezu, K ;

Kolodner, RD ;

Haber, JE .

CELL, 1998, 94 (03) :399-409

[23] Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre [J].

Lisby, M ;

Mortensen, UH ;

Rothstein, R .

NATURE CELL BIOLOGY, 2003, 5 (06) :572-577

[24] RAD51C is required for Holliday junction processing in mammalian cells [J].

Liu, YL ;

Masson, JY ;

Shah, R ;

O'Regan, P ;

West, SC .

SCIENCE, 2004, 303 (5655) :243-246

[25] The bacterial REcA protein and the recombinational DNA repair of stalled replication forks [J].

Lusetti, SL ;

Cox, MM .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :71-100

[26] Identification and purification of two distinct complexes containing the five RAD51 paralogs [J].

Masson, JY ;

Tarsounas, MC ;

Stasiak, AZ ;

Stasiak, A ;

Shah, R ;

McIlwraith, MJ ;

Benson, FE ;

West, SC .

GENES & DEVELOPMENT, 2001, 15 (24) :3296-3307

[27]

MIYAZAKI T, 2004, IN PRESS EMBO J

[28] RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: A universal step of recombinational repair [J].

Morimatsu, K ;

Kowalczykowski, SC .

MOLECULAR CELL, 2003, 11 (05) :1337-1347

[29] SIMILARITY OF THE YEAST RAD51 FILAMENT TO THE BACTERIAL RECA FILAMENT [J].

OGAWA, T ;

YU, X ;

SHINOHARA, A ;

EGELMAN, EH .

SCIENCE, 1993, 259 (5103) :1896-1899

[30] Generating crossovers by resolution of nicked Holliday junctions: A role for Mus81-Eme1 in meiosis [J].

Osman, F ;

Dixon, J ;

Doe, CL ;

Whitby, MC .

MOLECULAR CELL, 2003, 12 (03) :761-774

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