Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

被引：24

作者：

Daniel, Kevin B. ^{[1
]}

Callmann, Cassandra E. ^{[1
]}

Gianneschi, Nathan C. ^{[1
]}

Cohen, Seth M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 10期

基金：

美国国家卫生研究院;

关键词：

OPENING METATHESIS POLYMERIZATION; NADPH OXIDASE; SUPRAMOLECULAR SWITCHES; MYOCARDIAL-INFARCTION; OLEFIN METATHESIS; POLYMERS; DELIVERY; ACCUMULATION; INVASION; TISSUE;

D O I：

10.1039/c5cc09164k

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

引用

页码：2126 / 2128

页数：3

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