Nagelamides Q and R, Novel Dimeric Bromopyrrole Alkaloids from Sponges Agelas sp.

被引：41

作者：

Araki, Atsushi ^{[1
]}

Kubota, Takaaki ^{[1
]}

Aoyama, Kazuki ^{[2
]}

Mikami, Yuzuru ^{[2
]}

Fromont, Jane ^{[3
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Med Mycol Res Ctr, Chiba 2600856, Japan

[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 08期

关键词：

PYRROLE-IMIDAZOLE ALKALOIDS; SCEPTRIN; OROIDIN;

D O I：

10.1021/ol900328c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated from Okinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

引用

页码：1785 / 1788

页数：4

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