Two novel pyrrole-imidazole alkaloids from the Mediterranean sponge Agelas oroides

被引：91

作者：

Fattorusso, E ^{[1
]}

Taglialatela-Scafati, O ^{[1
]}

机构：

[1] Univ Naples, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 50期

关键词：

marine metabolites; biologically active compounds; alkaloids; stereochemistry;

D O I：

10.1016/S0040-4039(00)01764-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel pyrrole-imidazole alkaloids cyclooroidin (7) and taurodispacamide A (8) have been isolated from the Mediterranean sponge Agelas oroides, and their structures established from spectroscopic data. Although both these alkaloids may be conceived as derivatives of the C11N5 skeleton of the known oroidin (1), remarkably cyclooroidin (7) possesses the unprecedented N1/C9 connection. Tauro-dispacamide A (8) exhibited a good antihistaminic activity, tested on the isolated guinea pig ileum. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9917 / 9922

页数：6

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