Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine

被引：21

作者：

Folegatti, Pedro M. ^{[1
]}

Bellamy, Duncan ^{[1
]}

Roberts, Rachel ^{[1
]}

Powlson, Jonathan ^{[1
]}

Edwards, Nick J. ^{[1
]}

Mair, Catherine E. ^{[1
]}

Bowyer, Georgina ^{[1
]}

Poulton, Ian ^{[1
]}

Mitton, Celia H. ^{[1
]}

Green, Nicky ^{[2
]}

Berrie, Eleanor ^{[2
]}

Lawrie, Alison M. ^{[1
]}

Hill, Adrian V. S. ^{[1
]}

Ewer, Katie J. ^{[1
]}

Hermon-Taylor, John ^{[3
]}

Gilbert, Sarah C. ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, ORCRB, Roosevelt Dr, Oxford OX3 7DQ, England

[2] Univ Oxford, Churchill Hosp, Clin BioMfg Facil, Oxford OX3 7JT, England

[3] Kings Coll London, Fac Life Sci & Med, Dept Nutr Sci, Franklin Wilkins Bldg, London SE1 9NH, England

来源：

VACCINES | 2019年 / 7卷 / 02期

关键词：

viral vector; vaccine; T-cell; Mycobacterium avium subsp; paratuberculosis; CROHNS-DISEASE; BOOST VACCINE; CHIMPANZEE ADENOVIRUS; GAG/POL/NEF VACCINE; CLINICAL-ASSESSMENT; PARATUBERCULOSIS; IMMUNITY; PRIME; HYPOTHESES; EFFICACY;

D O I：

10.3390/vaccines7020040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Adenovirus vectored vaccines are a highly effective strategy to induce cellular immune responses which are particularly effective against intracellular pathogens. Recombinant simian adenovirus vectors were developed to circumvent the limitations imposed by the use of human adenoviruses due to widespread seroprevalence of neutralising antibodies. We have constructed a replication deficient simian adenovirus-vectored vaccine (ChAdOx2) expressing 4 genes from the Mycobacterium avium subspecies paratuberculosis (AhpC, Gsd, p12 and mpa). Safety and T-cell immunogenicity results of the first clinical use of the ChAdOx2 vector are presented here. The trial was conducted using a three-plus-three' dose escalation study design. We demonstrate the vaccine is safe, well tolerated and immunogenic.

引用

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