A DNA-templated synthesis of encoded small molecules by DNA self-assembly

被引：26

作者：

Cao, Cheng ^{[1
]}

Zhao, Peng ^{[1
]}

Li, Ze ^{[1
]}

Chen, Zitian ^{[3
,4
]}

Huang, Yanyi ^{[3
,4
]}

Bai, Yu ^{[1
]}

Li, Xiaoyu ^{[1
,2
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, BNLMS, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China

[2] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Key Lab Chem Genom, Shenzhen 518055, Peoples R China

[3] Peking Univ, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China

[4] Peking Univ, Coll Engn, Beijing 100871, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 75期

关键词：

IN-VITRO SELECTION; CHEMICAL LIBRARIES; COMBINATORIAL CHEMISTRY; ORGANIC-SYNTHESIS; INHIBITORS; DISCOVERY; MACROCYCLES; TRANSLATION; INFLUENZA; DESIGN;

D O I：

10.1039/c4cc03380a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.

引用

页码：10997 / 10999

页数：3

共 33 条

[1] ENCODED COMBINATORIAL CHEMISTRY [J].

BRENNER, S ;

LERNER, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5381-5383

[2] Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions [J].

Buller, Fabian ;

Mannocci, Luca ;

Zhang, Yixin ;

Dumelin, Christoph E. ;

Scheuermann, Joerg ;

Neri, Dario .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (22) :5926-5931

[3] Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds [J].

Buller, Fabian ;

Steiner, Martina ;

Frey, Katharina ;

Mircsof, Dennis ;

Scheuermann, Joerg ;

Kalisch, Markus ;

Buehlmann, Peter ;

Supuran, Claudiu T. ;

Neri, Dario .

ACS CHEMICAL BIOLOGY, 2011, 6 (04) :336-344

[4] Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition [J].

Buller, Fabian ;

Zhang, Yixin ;

Scheuermann, Joerg ;

Schaefer, Juliane ;

Buehlmann, Peter ;

Neri, Dario .

CHEMISTRY & BIOLOGY, 2009, 16 (10) :1075-1086

[5] Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis [J].

Calderone, CT ;

Liu, DR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (45) :7383-7386

[6] Selecting chemicals: the emerging utility of DNA-encoded libraries [J].

Clark, Matthew A. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (03) :396-403

[7] Design, synthesis and selection of DNA-encoded small-molecule libraries [J].

Clark, Matthew A. ;

Acharya, Raksha A. ;

Arico-Muendel, Christopher C. ;

Belyanskaya, Svetlana L. ;

Benjamin, Dennis R. ;

Carlson, Neil R. ;

Centrella, Paolo A. ;

Chiu, Cynthia H. ;

Creaser, Steffen P. ;

Cuozzo, John W. ;

Davie, Christopher P. ;

Ding, Yun ;

Franklin, G. Joseph ;

Franzen, Kurt D. ;

Gefter, Malcolm L. ;

Hale, Steven P. ;

Hansen, Nils J. V. ;

Israel, David I. ;

Jiang, Jinwei ;

Kavarana, Malcolm J. ;

Kelley, Michael S. ;

Kollmann, Christopher S. ;

Li, Fan ;

Lind, Kenneth ;

Mataruse, Sibongile ;

Medeiros, Patricia F. ;

Messer, Jeffrey A. ;

Myers, Paul ;

O'Keefe, Heather ;

Oliff, Matthew C. ;

Rise, Cecil E. ;

Satz, Alexander L. ;

Skinner, Steven R. ;

Svendsen, Jennifer L. ;

Tang, Lujia ;

van Vloten, Kurt ;

Wagner, Richard W. ;

Yao, Gang ;

Zhao, Baoguang ;

Morgan, Barry A. .

NATURE CHEMICAL BIOLOGY, 2009, 5 (09) :647-654

[8] DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles [J].

Daguer, Jean Pierre ;

Ciobanu, Mihai ;

Alvarez, Susana ;

Barluenga, Sofia ;

Winssinger, Nicolas .

CHEMICAL SCIENCE, 2011, 2 (04) :625-632

[9] Discovery of Thieno[3,2-4-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3 [J].

Disch, Jeremy S. ;

Evindar, Ghotas ;

Chiu, Cynthia H. ;

Blum, Charles A. ;

Dai, Han ;

Jin, Lei ;

Schuman, Eli ;

Lind, Kenneth E. ;

Belyanskaya, Svetlana L. ;

Deng, Jianghe ;

Coppo, Frank ;

Aquilani, Leah ;

Graybill, Todd L. ;

Cuozzo, John W. ;

Lavu, Siva ;

Mao, Cheney ;

Vlasuk, George P. ;

Perni, Robert B. .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (09) :3666-3679

[10] Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA [J].

Encinas, Lourdes ;

O'Keefe, Heather ;

Neu, Margarete ;

Remuinan, Modesto J. ;

Patel, Amish M. ;

Guardia, Ana ;

Davie, Christopher P. ;

Perez-Macias, Natalia ;

Yang, Hongfang ;

Convery, Maire A. ;

Messer, Jeff A. ;

Perez-Herran, Esther ;

Centrella, Paolo A. ;

Alvarez-Gomez, Daniel ;

Clark, Matthew A. ;

Huss, Sophie ;

O'Donovan, Gary K. ;

Ortega-Muro, Fatima ;

McDowell, William ;

Castaneda, Pablo ;

Arico-Muendel, Christopher C. ;

Pajk, Stane ;

Rullas, Joaquin ;

Angulo-Barturen, Inigo ;

Alvarez-Ruiz, Emilio ;

Mendoza-Losana, Alfonso ;

Pages, Lluis Ballell ;

Castro-Pichel, Julia ;

Evindar, Ghotas .

JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (04) :1276-1288

← 1 2 3 4 →