Recent advances in liver-directed gene therapy: implications for the treatment of dyslipidemia

被引：8

作者：

Oka, K

Davis, AR

Chan, L

机构：

[1] Baylor Coll Med, Texas Med Ctr, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2000年 / 11卷 / 02期

关键词：

D O I：

10.1097/00041433-200004000-00011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vectors because of their excellent gene-transfer efficiency. However, the first and second-generation adenoviral vectors used in these experiments are highly toxic and are associated with substantial morbidity and mortality. This article reviews current data on the properties of two novel vectors, the adenoassociated virus and the helper-dependent adenovirus that is devoid of all protein-encoding genes. Each type of vector has its advantages and drawbacks. They appear to be the most promising vectors to date for liver-directed gene transfer in the treatment of dyslipidemia. Curr Lipidol 11:179-186. (C) 2000 Lippincott Williams & Wilkins.

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收藏

页码：179 / 186

页数：8

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