Modular peptide recognition domains in eukaryotic signaling

被引：454

作者：

Kuriyan, J

Cowburn, D

机构：

[1] Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021

[2] Rockefeller University, New York, NY 10021

来源：

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | 1997年 / 26卷

关键词：

SH2; SH3; Src homology; tyrosine kinase; PTB; PDZ;

D O I：

10.1146/annurev.biophys.26.1.259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.

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页码：259 / 288

页数：30

相关论文

共 104 条

[41] STRUCTURES OF SH2 AND SH3 DOMAINS [J].

KURIYAN, J ;

COWBURN, D .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (06) :828-837

[42] MEASUREMENT OF THE BINDING OF TYROSYL PHOSPHOPEPTIDES TO SH2 DOMAINS - A REAPPRAISAL [J].

LADBURY, JE ;

LEMMON, MA ;

ZHOU, M ;

GREEN, J ;

BOTFIELD, MC ;

SCHLESSINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3199-3203

[43] CRYSTAL-STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE [J].

LEE, CH ;

KOMINOS, D ;

JACQUES, S ;

MARGOLIS, B ;

SCHLESSINGER, J ;

SHOELSON, SE ;

KURIYAN, J .

STRUCTURE, 1994, 2 (05) :423-438

[44] A SINGLE AMINO-ACID IN THE SH3 DOMAIN OF HCK DETERMINES ITS HIGH-AFFINITY AND SPECIFICITY IN BINDING TO HIV-1 NEF PROTEIN [J].

LEE, CH ;

LEUNG, B ;

LEMMON, MA ;

ZHENG, J ;

COWBURN, D ;

KURIYAN, J ;

SAKSELA, K .

EMBO JOURNAL, 1995, 14 (20) :5006-5015

[45] Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain [J].

Lee, CH ;

Saksela, K ;

Mirza, UA ;

Chait, BT ;

Kuriyan, J .

CELL, 1996, 85 (06) :931-942

[46] THERMODYNAMIC STUDIES OF TYROSYL-PHOSPHOPEPTIDE BINDING TO THE SH2 DOMAIN OF P56(LCK) [J].

LEMMON, MA ;

LADBURY, JE .

BIOCHEMISTRY, 1994, 33 (17) :5070-5076

[47]

LEMMON MA, 1994, J BIOL CHEM, V269, P31653

[48] CRITICAL RESIDUES IN AN SH3 DOMAIN FROM SEM-5 SUGGEST A MECHANISM FOR PROLINE-RICH PEPTIDE RECOGNITION [J].

LIM, WA ;

RICHARDS, FM .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (04) :221-225

[49] STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS [J].

LIM, WA ;

RICHARDS, FM ;

FOX, RO .

NATURE, 1994, 372 (6504) :375-379

[50] Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide [J].

Macias, MJ ;

Hyvonen, M ;

Baraldi, E ;

Schultz, J ;

Sudol, M ;

Saraste, M ;

Oschkinat, H .

NATURE, 1996, 382 (6592) :646-649

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